Endocrine Abstracts

A 19 year old university student who participated in athletics presented with secondary amenorrhoea. Examination revealed no features of endocrine disease. A pituitary profile showed normal serum thyroid function and prolactin, but undetectable LH, FSH, and oestradiol. Random serum GH level was detectable (9 milli units per litre), but IGF1 level was low, 72 (190-530 micrograms per litre). An OGTT demonstrated a paradoxical rise in her GH levels (3.5, 2.2, 38, 33, 20; mean GH ...